Thursday, February 21, 2019

Journal of Health Research and Reviews - Lupine Publishers



Therapeutic recombinant interferons and cytokines are being used to treat different diseases but these proteins can start immunogenic reactions. These reactions neutralize the effect of therapeutic proteins and make them useless. There are many factors responsible for causing and effecting immunogenicity including dosage, route of administration, genetic status, and polymorphism and Allergic responses. The body's first immune response against recombinant therapeutic cytokines is mediated by innate system, subsequently activating the adaptive immune system. The key factors in immunogenicity are the glycosylation and aggregated structure of therapeutic protein that distinguishes the protein/cytokine from self-proteins. There are many ways to reduce immunogenicity like to decrease the number of epitopes for T-cells or by screening the history of allergies. IFNs are basically proteins in nature many of which are related both in 3D structure and amino acid sequences. Recombinant Interferons are widely used these days against viral infections and cancers. In this review the antiproliferative activity and the effects of various recombinant human interferons on the cytotoxic and cytostatic activity of natural killer cells and monocytes are discussed in detail- Lupine Publishers.


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Wednesday, January 2, 2019

Gender difference in learning disabled children Neuropsychological Review(RRHOAJ)-Lupine Publishers





This review aimed to investigate the gender differences in learning disabilities among children. It is highlighted the nature of learning disabilities, and reviewed the gender differences on one hand, and explanation of theoretical background on the other hand. Finally, it is centred on the neuropsychology of these complicated behavioral phenomena. The conclusion of this article is that we are in the midst of investigating differences between male and female from multidimensional and methodological approaches because there are some critical issues regarding the assessing this complicated behavioural phenomena.

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Friday, December 28, 2018

To Examine the Relationship and Strength of Alcohol- Related Intimate Partner Violence in sub-Saharan Africa (RRHOAJ)-Lupine Publishers



Alcohol-related intimate partner violence (IPV) is a serious public health issue which has attracted a lot of research and debates. While some studies have reported the relationship between alcohol and IPV to be linear, others have reported threshold effects. While some studies have found the link to be strong, others have reported weak or no association. Using Logistic regression and meta-analysis, the relationship, strength of relationship and possible moderators of the alcohol-IPV link are investigated in ten sub-Saharan African countries. The results indicates that while alcohol consumption is associated with IPV in three of the countries, alcohol abuse was associated with IPV in the other seven countries lending support for both the linear and threshold effects in sub-Saharan Africa. The meta-analysis showed a strong association between alcohol and physical IPV while a weaker association was observed for the alcohol- sexual IPV link. Moderator analysis showed that the strength of the alcohol-IPV link in sub-Saharan Africa varies with wealth index, marital length, and marital status, and jealousy, place of residence and justification of the use of violence. The nature of moderation was different between countries. The results of this study can be applied to plan country specific and multi-faceted intervention programs.



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Thursday, December 27, 2018

Immunogeneicity of Recombinant Therapeutic Interferon Alpha(RRHOAJ)-LupinePublishers




Therapeutic recombinant interferons and cytokines are being used to treat different diseases but these proteins can start immunogenic reactions. These reactions neutralize the effect of therapeutic proteins and make them useless. There are many factors responsible for causing and effecting immunogenicity including dosage, route of administration, genetic status, and polymorphism and Allergic responses. The body's first immune response against recombinant therapeutic cytokines is mediated by innate system, subsequently activating the adaptive immune system. The key factors in immunogenicity are the glycosylation and aggregated structure of therapeutic protein that distinguishes the protein/cytokine from self-proteins. There are many ways to reduce immunogenicity like to decrease the number of epitopes for T-cells or by screening the history of allergies. IFNs are basically proteins in nature many of which are related both in 3D structure and amino acid sequences. Recombinant Interferons are widely used these days against viral infections and cancers. In this review the antiproliferative activity and the effects of various recombinant human interferons on the cytotoxic and cytostatic activity of natural killer cells and monocytes are discussed in detail.





For more LupinePublishers Open AccessJournals Please visit our website:http://www.lupinepublishers.com/

 

Wednesday, December 26, 2018

Gender difference in learning disabled children Neuropsychological review(RRHOAJ)-Lupine Publishers



This review aimed to investigate the gender differences in learning disabilities among children. It is highlighted the nature of learning disabilities, and reviewed the gender differences on one hand, and explanation of theoretical background on the other hand. Finally, it is centred on the neuropsychology of these complicated behavioral phenomena. The conclusion of this article is that we are in the midst of investigating differences between male and female from multidimensional and methodological approaches because there are some critical issues regarding the assessing this complicated behavioural phenomena.

For more Lupine Publishers Open Access Journals Please visit our website:http://www.lupinepublishers.com/

Journal of Health Research and Reviews - Lupine Publishers

Immunogeneicity of Recombinant Therapeutic Interferon Alpha by Hafiza Rida Farooq Chudhary in RRHOAJ - Lupine Publishers. Therapeu...