Wednesday, June 19, 2019

Journal of Research and Review- Lupine Publishers



Therapeutic recombinant interferons and cytokines are being used to treat different diseases but these proteins can start immunogenic reactions. These reactions neutralize the effect of therapeutic proteins and make them useless. There are many factors responsible for causing and effecting immunogenicity including dosage, route of administration, genetic status, and polymorphism and Allergic responses. The body’s first immune response against recombinant therapeutic cytokines is mediated by innate system, subsequently activating the adaptive immune system. The key factors in immunogenicity are the glycosylation and aggregated structure of therapeutic protein that distinguishes the protein/cytokine from self-proteins. There are many ways to reduce immunogenicity like to decrease the number of epitopes for T-cells or by screening the history of allergies. IFNs are basically proteins in nature many of which are related both in 3D structure and amino acid sequences. Recombinant Interferons are widely used these days against viral infections and cancers. In this review the antiproliferative activity and the effects of various recombinant human interferons on the cytotoxic and cytostatic activity of natural killer cells and monocytes are discussed in detail. Many diseases are being treated with drugs having protein nature. These exogenous proteins having therapeutic role are used as a replacement therapy for self-proteins. These Protein therapeutics are checked and analyzed to maintain biosafety measures and toxicity, viral and bacterial contaminations are removed. Beyond checking these measure there is immune response to a protein drug that is called "immunogenicity" can neutralize the effect of therapeutic cytokine (Barandun and others [1]; Dasgupta and others [2]). The concept was that 'self' derived protein therapeutics like recombinant human cytokines IFNβi-3 IFNα4,5 GM-CSF6 and human anti-TNFa7,8 antibodies will not cause immunogenicity.

For more information click on below link

For more Lupine Open access publishers go through the link

For click Journal of Research and Review below link

Tuesday, June 18, 2019

Medical Care Research and Review- Lupine Publishers



This review aimed to investigate the gender differences in learning disabilities among children. It is highlighted the nature of learningdisabilities, and reviewed the gender differences on one hand, and explanation of theoretical background on the other hand. Finally, it is centred on the neuropsychology of these complicated behavioral phenomena. The conclusion of this article is that we are in the midst of investigating differences between male and female from multidimensional and methodological approaches because there are some critical issues regarding the assessing this complicated behavioural phenomena. Learning disabilities (LD) are one of the most significant causes of school failure and may result from different causes and cognitive processes. "LD" refers to a variety of disorders that affect the acquisition, retention, understanding, organization or use of verbal and/ or non-verbal information. According to the definition, learning disabilities are due to genetic, congenital and acquired neurobiological factors that result in impairments in one or more psychological processes related to learning. In view of the neurobio psychological, nature of the disability, the formulation and communication of a diagnosis of learning disabilities is complex process that requires professional training and skill for assessing, and knowing the gender differences of neuropsychological structure of the brain [1]. LDs are specific not global impairments and as such are distinct from intellectual disabilities.

For more information click on below link

For more Lupine Open access publishers go through the link

For click Medical Care Research and Review below link

Monday, June 17, 2019

Lupine Publishers Surgery Case Studies Journal: Lupine Publishers - Journal of Surgery

Lupine Publishers Surgery Case Studies Journal: Lupine Publishers - Journal of Surgery: Acute Liver Failure and Thyrotoxicosis Managed with Liver Transplant and Thyroidectomy by  Gerardo Tamayo Enriquez in  Surgery & Ca...

Lupine Publishers Journal of Otolaryngology: Lupine Publishers - Journal of Otolaryngology

Lupine Publishers Journal of Otolaryngology: Lupine Publishers - Journal of Otolaryngology: The Reasons Behind the Trending of Facial PlasticSurgery in Saudi Arabia by Almuhaya Reham in SJO - Lupinepublishers Background: No...

Lupine Publishers: Civil Engineering Research Journal-Lupine Publishe...

Lupine Publishers: Civil Engineering Research Journal-Lupine Publishe...: Failure Analysis of Thermo-Mechanically Treated (TMT) Bar During Bending Operation: A Metallurgical Investigation by Souvik Das in Trends...

Medical Care Research and Review- Lupine Publishers




Alcohol-related intimate partner violence (IPV) is a serious public health issue which has attracted a lot of research and debates. While some studies have reported the relationship between alcohol and IPV to be linear, others have reported threshold effects. While some studies have found the link to be strong, others have reported weak or no association. Using Logistic regression and meta-analysis, the relationship, strength of relationship and possible moderators of the alcohol-IPV link are investigated in ten sub-Saharan African countries. The results indicates that while alcohol consumption is associated with IPV in three of the countries, alcohol abuse was associated with IPV in the other seven countries lending support for both the linear and threshold effects in sub-Saharan Africa. The meta-analysis showed a strong association between alcohol and physical IPV while a weaker association was observed for the alcoholsexualIPV link. Moderator analysis showed that the strength of the alcohol-IPV link in sub-Saharan Africa varies with wealth index, marital length, and marital status, and jealousy, place of residence and justification of the use of violence. The nature of moderation was different between countries. The results of this study can be applied to plan country specific and multi-faceted intervention programs.

For more information click on below link
https://lupinepublishers.com/research-and-reviews-journal/fulltext/to-examine-the-relationship-and-strength-of-alcoholrelated-intimate-partner-violence-in-sub-saharan-africa.ID.000110.php
https://lupinepublishers.com/research-and-reviews-journal/pdf/RRHOAJ.MS.ID.000110.pdf

For more Lupine Open access publishers go through the link
https://lupinepublishers.us/

For click Medical Care Research and Review below link
https://lupinepublishers.com/research-and-reviews-journal/

Journal of Research and Review- Lupine Publishers

Immunogeneicity of Recombinant TherapeuticInterferon Alpha by  Hafiza Rida Farooq Chudhary in  Research and Reviews on Healthcare: Ope...