Monday, February 25, 2019

Journal of Health Research and Reviews - Lupine Publishers

Heat wave killings in Pakistan and possible strategies to prevent the future heat wave fatalitie by Syed Zawar Shah in RRHOAJ- Lupine Publishers


There is near unanimous scientific consensus that greenhouse gas emissions generated by human activity will change Earth's climate. The recent (globally averaged) warming by 0.5°C is partly attributable to such anthropogenic emissions. Climate change will affect human health in many ways-most adversely. Heat waves are the most fatal type of weather situations and they happen irregularly in different countries. Heat waves are well-known in other countries but the people of Pakistan became familiar with it in 2010 when the extremely high temperature was recorded at Mohenjo-Daro, which was the hottest temperature ever recorded in Asia. After this incident heat waves again knocked the boundary of Pakistan in 2015 and at this time it caught attention because it resulted in a lot of deaths due to hyperthermia. Heat waves form when high pressure aloft become stronger and remains over a region for several days up to several weeks. Areas of high population having dense accommodation and poor people are at risk to the adverse effects of heat waves. Government should take steps to prevent deaths by investing in the electrical infrastructure. Besides this, public awareness is also important to minimize the loss- Lupine Publishers.

 

https://lupinepublishers.com/research-and-reviews-journal/fulltext/heat-wave-killings-in-pakistan-and-possible-strategies-to-prevent-the-future-heat-wave-fatalities.ID.000113.php

https://lupinepublishers.com/research-and-reviews-journal/pdf/RRHOAJ.MS.ID.000113.pdf

https://lupinepublishers.com/research-and-reviews-journal/abstracts/heat-wave-killings-in-pakistan-and-possible-strategies-to-prevent-the-future-heat-wave-fatalities.ID.000113.php 


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Thursday, February 21, 2019

Journal of Health Research and Reviews - Lupine Publishers



Therapeutic recombinant interferons and cytokines are being used to treat different diseases but these proteins can start immunogenic reactions. These reactions neutralize the effect of therapeutic proteins and make them useless. There are many factors responsible for causing and effecting immunogenicity including dosage, route of administration, genetic status, and polymorphism and Allergic responses. The body's first immune response against recombinant therapeutic cytokines is mediated by innate system, subsequently activating the adaptive immune system. The key factors in immunogenicity are the glycosylation and aggregated structure of therapeutic protein that distinguishes the protein/cytokine from self-proteins. There are many ways to reduce immunogenicity like to decrease the number of epitopes for T-cells or by screening the history of allergies. IFNs are basically proteins in nature many of which are related both in 3D structure and amino acid sequences. Recombinant Interferons are widely used these days against viral infections and cancers. In this review the antiproliferative activity and the effects of various recombinant human interferons on the cytotoxic and cytostatic activity of natural killer cells and monocytes are discussed in detail- Lupine Publishers.


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