Immunogeneicity of Recombinant Therapeutic Interferon Alpha by Hafiza Rida Farooq Chudhary in Research and Reviews on Healthcare: Open Access Journal in Lupine Publishers
Therapeutic recombinant interferons and cytokines are being used to
treat different diseases but these proteins can start immunogenic
reactions. These reactions neutralize the effect of therapeutic proteins
and make them useless. There are many factors responsible for causing
and effecting immunogenicity including dosage, route of administration,
genetic status, and polymorphism and Allergic responses. The body's
first immune response against recombinant therapeutic cytokines is
mediated by innate system, subsequently activating the adaptive immune
system. The key factors in immunogenicity are the glycosylation and
aggregated structure of therapeutic protein that distinguishes the
protein/cytokine from self-proteins. There are many ways to reduce
immunogenicity like to decrease the number of epitopes for T-cells or by
screening the history of allergies. IFNs are basically proteins in
nature many of which are related both in 3D structure and amino acid
sequences. Recombinant Interferons are widely used these days against
viral infections and cancers. In this review the antiproliferative
activity and the effects of various recombinant human interferons on the
cytotoxic and cytostatic activity of natural killer cells and monocytes
are discussed in detail.
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