Journal of Health Research and Reviews - Lupine Publishers

Topical "Medistick" Of Antifungal, the New Future of Drug-Cosmetic by  Bhupendra G Prajapati in RRHOAJ - Lupine Publishers

Main aim of developing medicated stick is to cure topical problems and also for beauty purpose by natural ingredients. This formulation is combination of both branches (drug-cosmetic).The drug used in the formulation is Ketoconazole which is used for antifungal therapy Pre formulation studies revealed that API and excipients were found to be compatible. For the formulation of medstick self emulsify drug delivery system was used. Take a solubility profile then three basic preliminary trials taken for making SEDDS. Optimize the SEDDS. This selection is done by concentration of bees wax, concentration of carnauba wax, concentration of castor oil and concentration of Isopropyl myristate. Evaluation test like breaking load test, softening point, permeability, melting point and antifungal activity etc was performed on the finalized formulation- Lupire Publishers.

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Journal of Health Research and Reviews - Lupine Publishers

Heat wave killings in Pakistan and possible strategies to prevent the future heat wave fatalitie by Syed Zawar Shah in RRHOAJ- Lupine Publishers

There is near unanimous scientific consensus that greenhouse gas emissions generated by human activity will change Earth's climate. The recent (globally averaged) warming by 0.5°C is partly attributable to such anthropogenic emissions. Climate change will affect human health in many ways-most adversely. Heat waves are the most fatal type of weather situations and they happen irregularly in different countries. Heat waves are well-known in other countries but the people of Pakistan became familiar with it in 2010 when the extremely high temperature was recorded at Mohenjo-Daro, which was the hottest temperature ever recorded in Asia. After this incident heat waves again knocked the boundary of Pakistan in 2015 and at this time it caught attention because it resulted in a lot of deaths due to hyperthermia. Heat waves form when high pressure aloft become stronger and remains over a region for several days up to several weeks. Areas of high population having dense accommodation and poor people are at risk to the adverse effects of heat waves. Government should take steps to prevent deaths by investing in the electrical infrastructure. Besides this, public awareness is also important to minimize the loss- Lupine Publishers.

 

https://lupinepublishers.com/research-and-reviews-journal/fulltext/heat-wave-killings-in-pakistan-and-possible-strategies-to-prevent-the-future-heat-wave-fatalities.ID.000113.php

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Journal of Health Research and Reviews - Lupine Publishers

Immunogeneicity of Recombinant Therapeutic Interferon Alpha by Hafiza Rida Farooq Chudhary in RRHOAJ - Lupine Publishers.

Therapeutic recombinant interferons and cytokines are being used to treat different diseases but these proteins can start immunogenic reactions. These reactions neutralize the effect of therapeutic proteins and make them useless. There are many factors responsible for causing and effecting immunogenicity including dosage, route of administration, genetic status, and polymorphism and Allergic responses. The body's first immune response against recombinant therapeutic cytokines is mediated by innate system, subsequently activating the adaptive immune system. The key factors in immunogenicity are the glycosylation and aggregated structure of therapeutic protein that distinguishes the protein/cytokine from self-proteins. There are many ways to reduce immunogenicity like to decrease the number of epitopes for T-cells or by screening the history of allergies. IFNs are basically proteins in nature many of which are related both in 3D structure and amino acid sequences. Recombinant Interferons are widely used these days against viral infections and cancers. In this review the antiproliferative activity and the effects of various recombinant human interferons on the cytotoxic and cytostatic activity of natural killer cells and monocytes are discussed in detail- Lupine Publishers.

https://lupinepublishers.com/research-and-reviews-journal/fulltext/immunogeneicity-of-recombinant-therapeutic-interferon-alpha.ID.000112.php

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Gender difference in learning disabled children Neuropsychological Review(RRHOAJ)-Lupine Publishers

Gender difference in learning disabled children Neuropsychological Review by Mohamad Qasim Abdullah in Research and Reviews on Healthcare: Open Access Journal in Lupine publishers

This review aimed to investigate the gender differences in learning disabilities among children. It is highlighted the nature of learning disabilities, and reviewed the gender differences on one hand, and explanation of theoretical background on the other hand. Finally, it is centred on the neuropsychology of these complicated behavioral phenomena. The conclusion of this article is that we are in the midst of investigating differences between male and female from multidimensional and methodological approaches because there are some critical issues regarding the assessing this complicated behavioural phenomena.

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To Examine the Relationship and Strength of Alcohol- Related Intimate Partner Violence in sub-Saharan Africa (RRHOAJ)-Lupine Publishers

To Examine the Relationship and Strength of Alcohol- Related Intimate Partner Violence in sub-Saharan Africa by Ekpenyong MS in Research and Reviews on Healthcare: Open Access Journal in Lupine Publishers

Alcohol-related intimate partner violence (IPV) is a serious public health issue which has attracted a lot of research and debates. While some studies have reported the relationship between alcohol and IPV to be linear, others have reported threshold effects. While some studies have found the link to be strong, others have reported weak or no association. Using Logistic regression and meta-analysis, the relationship, strength of relationship and possible moderators of the alcohol-IPV link are investigated in ten sub-Saharan African countries. The results indicates that while alcohol consumption is associated with IPV in three of the countries, alcohol abuse was associated with IPV in the other seven countries lending support for both the linear and threshold effects in sub-Saharan Africa. The meta-analysis showed a strong association between alcohol and physical IPV while a weaker association was observed for the alcohol- sexual IPV link. Moderator analysis showed that the strength of the alcohol-IPV link in sub-Saharan Africa varies with wealth index, marital length, and marital status, and jealousy, place of residence and justification of the use of violence. The nature of moderation was different between countries. The results of this study can be applied to plan country specific and multi-faceted intervention programs.

https://www.lupinepublishers.com/research-and-reviews-journal/abstracts/to-examine-the-relationship-and-strength-of-alcoholrelated-intimate-partner-violence-in-sub-saharan-africa.ID.000110.php

https://www.lupinepublishers.com/research-and-reviews-journal/pdf/RRHOAJ.MS.ID.000110.pdf

https://www.lupinepublishers.com/research-and-reviews-journal/fulltext/to-examine-the-relationship-and-strength-of-alcoholrelated-intimate-partner-violence-in-sub-saharan-africa.ID.000110.php

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Immunogeneicity of Recombinant Therapeutic Interferon Alpha(RRHOAJ)-LupinePublishers

Immunogeneicity of Recombinant Therapeutic Interferon Alpha by  Hafiza Rida Farooq Chudhary in Research and Reviews on Healthcare: Open Access Journal in Lupine Publishers

Therapeutic recombinant interferons and cytokines are being used to treat different diseases but these proteins can start immunogenic reactions. These reactions neutralize the effect of therapeutic proteins and make them useless. There are many factors responsible for causing and effecting immunogenicity including dosage, route of administration, genetic status, and polymorphism and Allergic responses. The body's first immune response against recombinant therapeutic cytokines is mediated by innate system, subsequently activating the adaptive immune system. The key factors in immunogenicity are the glycosylation and aggregated structure of therapeutic protein that distinguishes the protein/cytokine from self-proteins. There are many ways to reduce immunogenicity like to decrease the number of epitopes for T-cells or by screening the history of allergies. IFNs are basically proteins in nature many of which are related both in 3D structure and amino acid sequences. Recombinant Interferons are widely used these days against viral infections and cancers. In this review the antiproliferative activity and the effects of various recombinant human interferons on the cytotoxic and cytostatic activity of natural killer cells and monocytes are discussed in detail.

https://lupinepublishers.com/research-and-reviews-journal/abstracts/immunogeneicity-of-recombinant-therapeutic-interferon-alpha.ID.000112.php 

https://lupinepublishers.com/research-and-reviews-journal/pdf/RRHOAJ.MS.ID.000112.pdf 

https://lupinepublishers.com/research-and-reviews-journal/fulltext/immunogeneicity-of-recombinant-therapeutic-interferon-alpha.ID.000112.php 

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